Ewas Catalog Tools#

Configuration File: ewas_catalog_tools.json Tool Type: Local Tools Count: 2

This page contains all tools defined in the ewas_catalog_tools.json configuration file.

Available Tools#

EWASCatalog_search_by_cpg (Type: EWASCatalogTool)#

NOTE (re-checked 2026-11-01): the 503 reported on 2026-10-09 is gone, but the catalogue is now HT…

EWASCatalog_search_by_cpg tool specification

Tool Information:

  • Name: EWASCatalog_search_by_cpg

  • Type: EWASCatalogTool

  • Description: NOTE (re-checked 2026-11-01): the 503 reported on 2026-10-09 is gone, but the catalogue is now HTTPS-only – the old http://ewascatalog.org/api/ answers 404, and this tool has been moved to https://. Look up all published epigenome-wide association study (EWAS) results for one CpG methylation site from the EWAS Catalog (MRC-IEU). Returns trait, effect size, tissue, cohort, and publication for every association, ranked by significance. Example: cpg_id=’cg05575921’ (AHRR, the strongest known smoking-methylation signal).

Parameters:

  • cpg_id (string) (required) Illumina CpG probe identifier, e.g. ‘cg05575921’.

  • limit ([‘integer’, ‘null’]) (optional) Max associations to return, 1-200. Default 50.

Example Usage:

query = {
    "name": "EWASCatalog_search_by_cpg",
    "arguments": {
        "cpg_id": "example_value"
    }
}
result = tu.run(query)

EWASCatalog_search_by_gene (Type: EWASCatalogTool)#

NOTE (re-checked 2026-11-01): the 503 reported on 2026-10-09 is gone, but the catalogue is now HT…

EWASCatalog_search_by_gene tool specification

Tool Information:

  • Name: EWASCatalog_search_by_gene

  • Type: EWASCatalogTool

  • Description: NOTE (re-checked 2026-11-01): the 503 reported on 2026-10-09 is gone, but the catalogue is now HTTPS-only (the old http:// form answers 404) and it cannot deliver its largest gene payloads: gene=AHRR announces Content-Length 2751412 and the connection is closed after 1.57-1.85 MB, at a different offset on every attempt, so that one result set is unobtainable and the tool says so rather than failing to parse. Use EWASAtlas_search_by_gene (EWAS Atlas, curated independently) for a gene this one truncates. Look up all published epigenome-wide association study (EWAS) results annotated to one gene from the EWAS Catalog (MRC-IEU), across every CpG site mapped to it. Returns trait, effect size, tissue, cohort, and publication for each, ranked by significance. Example: gene_symbol=’CPT1A’ (a canonical smoking/metabolic methylation locus, 1941 associations).

Parameters:

  • gene_symbol (string) (required) HGNC gene symbol, e.g. ‘AHRR’, ‘TP53’.

  • limit ([‘integer’, ‘null’]) (optional) Max associations to return, 1-200. Default 50.

Example Usage:

query = {
    "name": "EWASCatalog_search_by_gene",
    "arguments": {
        "gene_symbol": "example_value"
    }
}
result = tu.run(query)