ToolUniverse Documentation

Democratizing AI Scientists for Science

ToolUniverse is a unified ecosystem that transforms any large language model (LLM)—open or closed—into a powerful AI scientist. By standardizing how LLMs identify and call tools, it integrates over 1000 scientific resources, including machine learning models, datasets, APIs, and analysis packages.

With its AI-Tool Interaction Protocol, ToolUniverse provides a common interface for seamless communication between LLMs and tools, ensuring compatibility across platforms such as GPT, Claude, Gemini, and open-source models.

Get Started

Choose your path:

Using AI chat?

Choose AI Agent User

Integrate ToolUniverse with Claude, ChatGPT, Gemini, or other AI agents for interactive research.

Set Up ToolUniverse
Writing code?

Choose Python Developer

Use ToolUniverse’s Python API directly in your code, Jupyter notebooks, or custom applications.

Python Guide

What Can You Do?

AI Agent Skills - Specialized workflows combining 1000+ scientific tools:

Research Skills

Drug discovery, target analysis, disease research, literature reviews, protein design, binder discovery, precision oncology, and more

AI Agent Skills
Development Skills

Create new tools, fix failing tools, optimize descriptions, improve documentation quality, and enhance skill workflows

AI Agent Skills
Setup & Configuration

Install and configure ToolUniverse with MCP integration for any AI coding client (Cursor, Claude, Gemini, VS Code, etc.)

AI Agent Skills
General Purpose

General strategies for using ToolUniverse effectively: tool discovery, multi-hop queries, comprehensive research workflows

AI Agent Skills

View All Skills: Browse complete catalog with detailed descriptions and usage guides

Explore More

Browse 1000+ Tools

Complete tool catalog with examples

Available Tools
Expand ToolUniverse

Add custom tools and APIs

Navigation
Troubleshooting

Fix common issues

Troubleshooting Tutorial

Community & Support

Report Issues

Bug reports and feature requests

https://github.com/mims-harvard/ToolUniverse/issues
Visit Website

Try tools directly in browser

https://aiscientist.tools

Browse All Documentation - Complete sitemap

Democratizing AI agents for science with ToolUniverse.