Proteomicsdb Meltome Tools

Configuration File: proteomicsdb_meltome_tools.json Tool Type: Local Tools Count: 1

This page contains all tools defined in the proteomicsdb_meltome_tools.json configuration file.

Available Tools

ProteomicsDB_get_protein_meltome (Type: ProteomicsDBGetProteinMeltomeTool)

Get a protein’s thermal proteome profiling (meltome / TPP) melting curves from ProteomicsDB by ge…

ProteomicsDB_get_protein_meltome tool specification

Tool Information:

  • Name: ProteomicsDB_get_protein_meltome

  • Type: ProteomicsDBGetProteinMeltomeTool

  • Description: Get a protein’s thermal proteome profiling (meltome / TPP) melting curves from ProteomicsDB by gene symbol or UniProt accession. Each curve yields an apparent melting temperature (Tm) and fit quality (R^2 / p-value); a ligand-induced Tm shift is the basis of CETSA/TPP target deconvolution. Keyless. NOTE: the meltome covers SOLUBLE proteins — most membrane GPCRs (e.g. GLP1R) have no data.

Parameters:

  • gene_symbol ([‘string’, ‘null’]) (optional) HGNC gene symbol, e.g. ‘MAPK1’. Provide this OR uniprot_accession.

  • uniprot_accession ([‘string’, ‘null’]) (optional) UniProt accession, e.g. ‘P28482’. Provide this OR gene_symbol.

  • max_curves (integer) (optional) Max melting curves to return (default 25, max 200).

Example Usage:

query = {
    "name": "ProteomicsDB_get_protein_meltome",
    "arguments": {
    }
}
result = tu.run(query)