Open Genes Tools#

Configuration File: open_genes_tools.json Tool Type: Local Tools Count: 2

This page contains all tools defined in the open_genes_tools.json configuration file.

Available Tools#

OpenGenes_get_gene (Type: OpenGenesGeneTool)#

Get the aging/longevity profile of a human gene by symbol from Open Genes, a manually-curated agi…

OpenGenes_get_gene tool specification

Tool Information:

  • Name: OpenGenes_get_gene

  • Type: OpenGenesGeneTool

  • Description: Get the aging/longevity profile of a human gene by symbol from Open Genes, a manually-curated aging-gene database. Returns the gene’s aging mechanisms (e.g. INS/IGF-1 pathway dysregulation), functional clusters, associated disease categories, curator confidence level, expression change with age, and an evidence-count summary across study types (lifespan-increase studies, longevity associations, age-related changes, progeria associations, interventions). Use to assess whether and how a gene is implicated in aging. No API key required.

Parameters:

  • symbol (string) (required) Human gene symbol, e.g. ‘GHR’, ‘FOXO3’, ‘TP53’, ‘SIRT1’.

Example Usage:

query = {
    "name": "OpenGenes_get_gene",
    "arguments": {
        "symbol": "example_value"
    }
}
result = tu.run(query)

OpenGenes_search_genes (Type: OpenGenesSearchTool)#

Browse the complete Open Genes catalog of human aging/longevity genes with one-based page paginat…

OpenGenes_search_genes tool specification

Tool Information:

  • Name: OpenGenes_search_genes

  • Type: OpenGenesSearchTool

  • Description: Browse the complete Open Genes catalog of human aging/longevity genes with one-based page pagination and pages up to 1000 records. Metadata reports the exact gene count, total_pages, has_more, and next_page. Returns gene summaries with aging mechanisms, functional clusters, confidence level, and expression change. No API key required.

Parameters:

  • limit ([‘integer’, ‘null’]) (optional) Genes per page (default 20, max 1000).

  • page ([‘integer’, ‘null’]) (optional) One-based page number (default 1). Continue with metadata.next_page.

Example Usage:

query = {
    "name": "OpenGenes_search_genes",
    "arguments": {
    }
}
result = tu.run(query)