Opentarget 工具¶
Configuration File: opentarget_tools.json
Tool Type: Local
Tools Count: 55
此页面包含 opentarget_tools.json 配置文件中定义的所有工具。
可用工具¶
**OpenTargets_药物药物基因组学数据**（类型：OpenTarget）¶
检索特定药物的药物基因组学数据，包括证据等级和基因型注释…
OpenTargets_drug_pharmacogenomics_data 工具规格说明
工具信息：
名称：
OpenTargets_drug_pharmacogenomics_data类型：
OpenTarget描述：检索特定药物的药物基因组学数据，包括证据级别和基因型注释。
参数：
chemblId(string) (required) The ChEMBL ID of the drug (e.g., ‘CHEMBL25’ for aspirin, ‘CHEMBL1201583’ for pembrolizumab).
示例用法：
query = {
"name": "OpenTargets_drug_pharmacogenomics_data",
"arguments": {
"chemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_approved_indications_by_drug_chemblId**（类型：OpenTarget）¶
使用一组 ChEMBL ID 检索多个药物的详细信息。
OpenTargets_get_approved_indications_by_drug_chemblId 工具规范
工具信息：
名称:
OpenTargets_get_approved_indications_by_drug_chemblId类型：
OpenTarget描述：使用一组 ChEMBL ID 检索多个药物的详细信息。
参数：
chemblId(string) (required) The ChEMBL ID of the drug.
示例用法：
query = {
"name": "OpenTargets_get_approved_indications_by_drug_chemblId",
"arguments": {
"chemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_associated_diseases_by_drug_chemblId**（类型：OpenTarget）¶
根据临床试验数据，检索与特定药物 chemblId 相关的疾病列表。
OpenTargets_get_associated_diseases_by_drug_chemblId 工具规范
工具信息：
名称:
OpenTargets_get_associated_diseases_by_drug_chemblId类型：
OpenTarget描述：根据临床试验数据或上市后药物信息，检索与特定药物的 chemblId 相关的疾病列表。
参数：
chemblId(string) (required) The ChEMBL ID of the drug.
示例用法：
query = {
"name": "OpenTargets_get_associated_diseases_by_drug_chemblId",
"arguments": {
"chemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_associated_drugs_by_disease_efoId**（类型：OpenTarget）¶
根据疾病的 efoId 检索与特定疾病相关的已知药物。
OpenTargets_get_associated_drugs_by_disease_efoId 工具规范
工具信息：
名称:
OpenTargets_get_associated_drugs_by_disease_efoId类型：
OpenTarget描述：通过疾病的 efoId 检索与特定疾病相关的已知药物。
参数：
efoId(string) (required) The EFO ID of the disease.
示例用法：
query = {
"name": "OpenTargets_get_associated_drugs_by_disease_efoId",
"arguments": {
"efoId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_通过目标EnsemblID获取相关药物**（类型：OpenTarget）¶
获取与特定目标ensemblID相关的已知药物及信息（例如ID、名称、作用机制）…
OpenTargets_get_associated_drugs_by_target_ensemblID 工具规格说明
工具信息：
名称：
OpenTargets_get_associated_drugs_by_target_ensemblID类型：
OpenTarget描述：获取与特定靶点ensemblID相关的已知药物及其信息（例如ID、名称、作用机制），包括药物的临床试验阶段和作用机制。
参数：
ensemblId(string) (required) The Ensembl ID of the target.
示例用法：
query = {
"name": "OpenTargets_get_associated_drugs_by_target_ensemblID",
"arguments": {
"ensemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_根据疾病EFO ID获取相关表型**（类型：OpenTarget）¶
查找与指定疾病 efoId 相关的 HPO 表型。
OpenTargets_根据疾病EFO ID获取相关表型工具规范
工具信息：
名称：
OpenTargets_get_associated_phenotypes_by_disease_efoId类型：
OpenTarget描述：查找与指定疾病 efoId 相关的 HPO 表型。
参数：
efoId(string) (required) The efoId of a disease or phenotype.
示例用法：
query = {
"name": "OpenTargets_get_associated_phenotypes_by_disease_efoId",
"arguments": {
"efoId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_associated_targets_by_disease_efoId**（类型：OpenTarget）¶
根据 efoId 查找与特定疾病或表型相关的靶点。
OpenTargets_通过疾病EFO ID获取相关靶点工具规格说明
工具信息：
名称：
OpenTargets_get_associated_targets_by_disease_efoId类型：
OpenTarget描述：根据 efoId 查找与特定疾病或表型相关的靶点。
参数：
efoId(string) (required) The efoId of a disease or phenotype.
示例用法：
query = {
"name": "OpenTargets_get_associated_targets_by_disease_efoId",
"arguments": {
"efoId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_associated_targets_by_drug_chemblId**（类型：OpenTarget）¶
根据药物的作用机制，检索与特定药物 chemblId 相关联的靶点列表。
OpenTargets_get_associated_targets_by_drug_chemblId 工具规格说明
工具信息：
名称：
OpenTargets_get_associated_targets_by_drug_chemblId类型：
OpenTarget描述：根据药物的作用机制，检索与特定药物 chemblId 相关联的靶点列表。
参数：
chemblId(string) (required) The ChEMBL ID of the drug.
示例用法：
query = {
"name": "OpenTargets_get_associated_targets_by_drug_chemblId",
"arguments": {
"chemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_biological_mouse_models_by_ensemblID**（类型：OpenTarget）¶
检索生物小鼠模型，包括等位基因组成和遗传背景，用于s…
OpenTargets_get_biological_mouse_models_by_ensemblID 工具规格说明
工具信息：
名称：
OpenTargets_get_biological_mouse_models_by_ensemblID类型：
OpenTarget描述：检索生物小鼠模型，包括等位基因组成和遗传背景，针对特定靶标。
参数：
ensemblId(string) (required) The Ensembl ID of the target.
示例用法：
query = {
"name": "OpenTargets_get_biological_mouse_models_by_ensemblID",
"arguments": {
"ensemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_通过目标Ensembl ID获取化学探针**（类型：OpenTarget）¶
使用其 ensemblID 检索与特定靶点相关的化学探针。
OpenTargets_get_chemical_probes_by_target_ensemblID 工具规格说明
工具信息：
名称：
OpenTargets_get_chemical_probes_by_target_ensemblID类型：
OpenTarget描述：使用目标的 ensemblID 检索与之相关的化学探针。
参数：
ensemblId(string) (required) The Ensembl ID of the target for which to retrieve chemical probes.
示例用法：
query = {
"name": "OpenTargets_get_chemical_probes_by_target_ensemblID",
"arguments": {
"ensemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_disease_ancestors_parents_by_efoId**（类型：OpenTarget）¶
使用疾病 EFO ID 在本体中检索疾病的祖先和父节点。
OpenTargets_get_disease_ancestors_parents_by_efoId 工具规格说明
工具信息：
名称：
OpenTargets_get_disease_ancestors_parents_by_efoId类型：
OpenTarget描述：使用疾病 EFO ID 检索本体中的疾病祖先和父节点。
参数：
efoId(string) (required) The EFO ID of the disease.
示例用法：
query = {
"name": "OpenTargets_get_disease_ancestors_parents_by_efoId",
"arguments": {
"efoId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_disease_descendants_children_by_efoId**（类型：OpenTarget）¶
使用疾病的 EFO ID 检索本体中的疾病后代和子类。
OpenTargets_get_disease_descendants_children_by_efoId 工具规范
工具信息：
名称：
OpenTargets_get_disease_descendants_children_by_efoId类型：
OpenTarget描述：使用疾病 EFO ID 检索本体中的疾病后代和子类。
参数：
efoId(string) (required) The EFO ID of the disease.
示例用法：
query = {
"name": "OpenTargets_get_disease_descendants_children_by_efoId",
"arguments": {
"efoId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_disease_description_by_efoId**（类型：OpenTarget）¶
检索疾病描述、名称、数据库交叉引用、废弃术语及其状态…
OpenTargets_get_disease_description_by_efoId 工具规格说明
工具信息：
名称：
OpenTargets_get_disease_description_by_efoId类型：
OpenTarget描述：使用指定的 efoId 检索疾病描述、名称、数据库交叉引用、废弃术语及是否属于治疗领域。
参数：
efoId(string) (required) The EFO ID of the disease.
示例用法：
query = {
"name": "OpenTargets_get_disease_description_by_efoId",
"arguments": {
"efoId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_disease_id_description_by_name**（类型：OpenTarget）¶
根据疾病名称检索其efoId及其他详细信息。
OpenTargets_get_disease_id_description_by_name 工具规范
工具信息：
名称：
OpenTargets_get_disease_id_description_by_name类型：
OpenTarget描述：根据疾病名称检索其efoId及其他详细信息。
参数：
diseaseName(string) (required) The name of the disease to search for.
示例用法：
query = {
"name": "OpenTargets_get_disease_id_description_by_name",
"arguments": {
"diseaseName": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_disease_locations_by_efoId**（类型：OpenTarget）¶
使用疾病…检索疾病的直接位置和间接位置的疾病术语及其ID
OpenTargets_get_disease_locations_by_efoId 工具规格说明
工具信息：
名称：
OpenTargets_get_disease_locations_by_efoId类型：
OpenTarget描述：使用疾病的 EFO ID 检索疾病的直接位置和间接位置的疾病术语及其 ID。
参数：
efoId(string) (required) The EFO ID of the disease.
示例用法：
query = {
"name": "OpenTargets_get_disease_locations_by_efoId",
"arguments": {
"efoId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_disease_synonyms_by_efoId**（类型：OpenTarget）¶
通过其 EFO ID 检索疾病同义词。
OpenTargets_get_disease_synonyms_by_efoId 工具规格说明
工具信息：
名称：
OpenTargets_get_disease_synonyms_by_efoId类型：
OpenTarget描述：通过其 EFO ID 检索疾病同义词。
参数：
efoId(string) (required) The EFO ID of the disease.
示例用法：
query = {
"name": "OpenTargets_get_disease_synonyms_by_efoId",
"arguments": {
"efoId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_disease_therapeutic_areas_by_efoId**（类型：OpenTarget）¶
检索与特定疾病 efoId 相关的治疗领域。
OpenTargets_get_disease_therapeutic_areas_by_efoId 工具规格说明
工具信息：
名称：
OpenTargets_get_disease_therapeutic_areas_by_efoId类型：
OpenTarget描述：检索与特定疾病 efoId 相关的治疗领域。
参数：
efoId(string) (required) The EFO ID of the disease.
示例用法：
query = {
"name": "OpenTargets_get_disease_therapeutic_areas_by_efoId",
"arguments": {
"efoId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_通过目标Ensembl获取疾病表型**（类型：OpenTarget）¶
使用 ensemblId 查找与特定靶点相关的疾病或表型。
OpenTargets_get_diseases_phenotypes_by_target_ensembl 工具规格说明
工具信息：
名称：
OpenTargets_get_diseases_phenotypes_by_target_ensembl类型：
OpenTarget描述：使用 ensemblId 查找与特定靶点相关的疾病或表型。
参数：
ensemblId(string) (required) The ensemblId of a target.
示例用法：
query = {
"name": "OpenTargets_get_diseases_phenotypes_by_target_ensembl",
"arguments": {
"ensemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_drug_adverse_events_by_chemblId**（类型：OpenTarget）¶
检索针对特定药物 chemblId 报告的重要不良事件。
OpenTargets_get_drug_adverse_events_by_chemblId 工具规格说明
工具信息：
名称：
OpenTargets_get_drug_adverse_events_by_chemblId类型：
OpenTarget描述：检索针对特定药物 chemblId 报告的重要不良事件。
参数：
chemblId(string) (required) The ChEMBL ID of the drug.``page``（对象）（可选）分页设置。
示例用法：
query = {
"name": "OpenTargets_get_drug_adverse_events_by_chemblId",
"arguments": {
"chemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_drug_approval_status_by_chemblId**（类型：OpenTarget）¶
检索特定药物 chemblId 的审批状态。
OpenTargets_get_drug_approval_status_by_chemblId 工具规格说明
工具信息：
名称：
OpenTargets_get_drug_approval_status_by_chemblId类型：
OpenTarget描述：获取特定药物 chemblId 的审批状态。
参数：
chemblId(string) (required) The ChEMBL ID of the drug.
示例用法：
query = {
"name": "OpenTargets_get_drug_approval_status_by_chemblId",
"arguments": {
"chemblId": "example_value"
}
}
result = tu.run(query)
OpenTargets_get_drug_blackbox_status_by_chembl_ID (Type: OpenTarget)¶
通过 chemblId 查询特定药物的撤回状态和黑框警告状态。
OpenTargets_get_drug_blackbox_status_by_chembl_ID tool specification
工具信息：
Name:
OpenTargets_get_drug_blackbox_status_by_chembl_ID类型：
OpenTarget描述：通过 chemblId 查询特定药物的撤回状态和黑框警告状态。
参数：
chemblId(string) (required) The chemblId of a drug.
示例用法：
query = {
"name": "OpenTargets_get_drug_blackbox_status_by_chembl_ID",
"arguments": {
"chemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_drug_chembId_by_generic_name**（类型：OpentargetToolDrugNameMatch）¶
根据药物通用名获取药物的chemblId和描述。
OpenTargets_get_drug_chembId_by_generic_name 工具规格说明
工具信息：
名称：
OpenTargets_get_drug_chembId_by_generic_name类型：
OpentargetToolDrugNameMatch描述：根据药物通用名获取药物的chemblId和描述信息。
参数：
drugName(string) (required) The generic name of the drug for which the ID is required.
示例用法：
query = {
"name": "OpenTargets_get_drug_chembId_by_generic_name",
"arguments": {
"drugName": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_drug_description_by_chemblId**（类型：OpenTarget）¶
获取药物名称、首次批准年份、类型、交叉引用及最高临床试验阶段，基于…
OpenTargets_get_drug_description_by_chemblId 工具规范
工具信息：
名称:
OpenTargets_get_drug_description_by_chemblId类型：
OpenTarget描述：根据指定的chemblId获取药物名称、首次批准年份、类型、交叉引用以及最高临床试验阶段。
参数：
chemblId(string) (required) The ChEMBL ID of the drug.
示例用法：
query = {
"name": "OpenTargets_get_drug_description_by_chemblId",
"arguments": {
"chemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_drug_id_description_by_name**（类型：OpentargetToolDrugNameMatch）¶
根据药物通用名获取药物的chemblId和描述。
OpenTargets_get_drug_id_description_by_name 工具规范
工具信息：
名称:
OpenTargets_get_drug_id_description_by_name类型：
OpentargetToolDrugNameMatch描述：根据药物通用名获取药物的chemblId和描述信息。
参数：
drugName(string) (required) The name of the drug for which the ID is required.
示例用法：
query = {
"name": "OpenTargets_get_drug_id_description_by_name",
"arguments": {
"drugName": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_drug_indications_by_chemblId**（类型：OpenTarget）¶
获取指定药物的chemblId对应的适应症（可治疗的表型/疾病）。
OpenTargets_get_drug_indications_by_chemblId 工具规范
工具信息：
名称:
OpenTargets_get_drug_indications_by_chemblId类型：
OpenTarget描述：获取指定药物的化合物ChEMBL ID对应的可治疗表型/疾病信息。
参数：
chemblId(string) (required) The chemblId of the drug for which to retrieve treatable phenotypes information.
示例用法：
query = {
"name": "OpenTargets_get_drug_indications_by_chemblId",
"arguments": {
"chemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_drug_mechanisms_of_action_by_chemblId**（类型：OpenTarget）¶
使用 chemblId 检索与特定药物相关的作用机制。
OpenTargets_get_drug_mechanisms_of_action_by_chemblId 工具规范
工具信息：
名称:
OpenTargets_get_drug_mechanisms_of_action_by_chemblId类型：
OpenTarget描述：使用 chemblId 获取与特定药物相关的作用机制。
参数：
chemblId(string) (required) The ChEMBL ID of the drug.
示例用法：
query = {
"name": "OpenTargets_get_drug_mechanisms_of_action_by_chemblId",
"arguments": {
"chemblId": "example_value"
}
}
result = tu.run(query)
OpenTargets_get_drug_names_by_chemblId (Type: OpenTarget)¶
Get drug generic name and brand names (trade names) based on ChEMBL ID. Returns the drug name (ty…
OpenTargets_get_drug_names_by_chemblId tool specification
工具信息：
Name:
OpenTargets_get_drug_names_by_chemblId类型：
OpenTargetDescription: Get drug generic name and brand names (trade names) based on ChEMBL ID. Returns the drug name (typically generic name), trade names (brand names), and synonyms.
参数：
chemblId(string) (required) The ChEMBL ID of the drug.
示例用法：
query = {
"name": "OpenTargets_get_drug_names_by_chemblId",
"arguments": {
"chemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_drug_synonyms_by_chemblId**（类型：OpenTarget）¶
检索与特定药物的chemblId相关的同义词。
OpenTargets_get_drug_synonyms_by_chemblId 工具规范
工具信息：
名称:
OpenTargets_get_drug_synonyms_by_chemblId类型：
OpenTarget描述：检索与特定药物的 chemblId 相关的同义词。
参数：
chemblId(string) (required) The ChEMBL ID of the drug.
示例用法：
query = {
"name": "OpenTargets_get_drug_synonyms_by_chemblId",
"arguments": {
"chemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_drug_trade_names_by_chemblId**（类型：OpenTarget）¶
检索与特定药物的 chemblId 相关联的商品名。
OpenTargets_get_drug_trade_names_by_chemblId 工具规范
工具信息：
名称:
OpenTargets_get_drug_trade_names_by_chemblId类型：
OpenTarget描述：检索与特定药物的 chemblId 相关联的商品名。
参数：
chemblId(string) (required) The ChEMBL ID of the drug.
示例用法：
query = {
"name": "OpenTargets_get_drug_trade_names_by_chemblId",
"arguments": {
"chemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_drug_warnings_by_chemblId**（类型：OpenTarget）¶
使用 ChEMBL ID 检索特定药物的警告信息。
OpenTargets_get_drug_warnings_by_chemblId 工具规范
工具信息：
名称:
OpenTargets_get_drug_warnings_by_chemblId类型：
OpenTarget描述：使用 ChEMBL ID 检索特定药物的警告信息。
参数：
chemblId(string) (required) The ChEMBL ID of the drug.
示例用法：
query = {
"name": "OpenTargets_get_drug_warnings_by_chemblId",
"arguments": {
"chemblId": "example_value"
}
}
result = tu.run(query)
OpenTargets_get_evidence_by_datasource (Type: OpenTarget)¶
Get target-disease evidence from Open Targets filtered by configurable data sources. Unlike OpenT…
OpenTargets_get_evidence_by_datasource tool specification
工具信息：
Name:
OpenTargets_get_evidence_by_datasource类型：
OpenTargetDescription: Get target-disease evidence from Open Targets filtered by configurable data sources. Unlike OpenTargets_target_disease_evidence (intogen-only), this tool accepts any datasourceIds. Valid sources include: ot_genetics_portal, eva, eva_somatic, gene_burden, genomics_england, intogen, cancer_gene_census, chembl, crispr, europepmc, expression_atlas, gene2phenotype, orphanet, uniprot_literature, uniprot_variants, clingen, phewas_catalog, reactome, progeny, slapenrich, sysbio. Returns evidence rows with scores, literature references, and source attribution.
参数：
efoId(string) (optional) Disease EFO ID (e.g., ‘EFO_0000384’ for Crohn’s disease). Alternative to disease_name.ensemblId(string) (optional) Target Ensembl gene ID (e.g., ‘ENSG00000141510’ for TP53). Alternative to gene_symbol.gene_symbol(string) (optional) HGNC gene symbol (e.g., ‘TP53’, ‘BRCA1’). Auto-resolved to ensemblId.disease_name(string) (optional) Disease or phenotype name (e.g., ‘Crohn disease’). Auto-resolved to efoId.datasourceIds(array) (optional) List of datasource IDs to filter evidence. Examples: [‘chembl’, ‘europepmc’], [‘eva’, ‘clinvar’], [‘intogen’, ‘cancer_gene_census’]. Omit or pass empty array for all sources.size(integer) (optional) Maximum evidence rows to return (default: 50)
示例用法：
query = {
"name": "OpenTargets_get_evidence_by_datasource",
"arguments": {
}
}
result = tu.run(query)
**OpenTargets_get_gene_ontology_terms_by_goID**（类型：OpenTarget）¶
根据GO ID列表检索基因本体（Gene Ontology）术语。
OpenTargets_get_gene_ontology_terms_by_goID 工具规范
工具信息：
名称:
OpenTargets_get_gene_ontology_terms_by_goID类型：
OpenTarget描述：根据GO ID列表检索基因本体（Gene Ontology）术语。
参数：
goIds(array) (required) A list of Gene Ontology (GO) IDs to fetch the corresponding terms.
示例用法：
query = {
"name": "OpenTargets_get_gene_ontology_terms_by_goID",
"arguments": {
"goIds": ["item1", "item2"]
}
}
result = tu.run(query)
**OpenTargets_get_known_drugs_by_drug_chemblId**（类型：OpenTarget）¶
使用指定的chemblId获取已知药物及相关信息的列表。
OpenTargets_get_known_drugs_by_drug_chemblId 工具规范
工具信息：
名称:
OpenTargets_get_known_drugs_by_drug_chemblId类型：
OpenTarget描述：使用指定的chemblId获取已知药物及其相关信息的列表。
参数：
chemblId(string) (required) The ChEMBL ID of the drug.
示例用法：
query = {
"name": "OpenTargets_get_known_drugs_by_drug_chemblId",
"arguments": {
"chemblId": "example_value"
}
}
result = tu.run(query)
OpenTargets_get_parent_child_molecules_by_chembl_ID (Type: OpenTarget)¶
获取指定药物 chemblId 的父分子和子分子。
OpenTargets_get_parent_child_molecules_by_chembl_ID tool specification
工具信息：
Name:
OpenTargets_get_parent_child_molecules_by_chembl_ID类型：
OpenTarget描述：获取指定药物 chemblId 的父分子和子分子。
参数：
chemblId(string) (required) The ChEMBL ID of the drug.
示例用法：
query = {
"name": "OpenTargets_get_parent_child_molecules_by_chembl_ID",
"arguments": {
"chemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_publications_by_disease_efoId**（类型：OpenTarget）¶
检索与疾病 efoId 相关的出版物，包括 PubMed ID 和出版日期。
OpenTargets_get_publications_by_disease_efoId 工具规范
工具信息：
名称:
OpenTargets_get_publications_by_disease_efoId类型：
OpenTarget描述：检索与疾病 efoId 相关的出版物，包括 PubMed ID 和出版日期。
参数：
entityId(string) (required) The ID of the entity (efoId).``additionalIds``（数组）（可选）要在搜索中包含的附加ID列表。
``startYear``（整数）（可选）过滤器下限年份。
``startMonth``（整数）（可选）过滤器下限的月份。
``endYear``（整数）（可选）筛选器高端的年份。
``endMonth``（整数）（可选）筛选器上限的月份。
示例用法：
query = {
"name": "OpenTargets_get_publications_by_disease_efoId",
"arguments": {
"entityId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_publications_by_drug_chemblId**（类型：OpenTarget）¶
检索与药物 chemblId 相关的出版物，包括 PubMed ID 和出版日期。
OpenTargets_get_publications_by_drug_chemblId 工具规范
工具信息：
名称:
OpenTargets_get_publications_by_drug_chemblId类型：
OpenTarget描述：检索与药物 chemblId 相关的出版物，包括 PubMed ID 和出版日期。
参数：
entityId(string) (required) The ID of the entity (chemblId).``additionalIds``（数组）（可选）要在搜索中包含的附加ID列表。
``startYear``（整数）（可选）过滤器下限年份。
``startMonth``（整数）（可选）过滤器下限的月份。
``endYear``（整数）（可选）筛选器高端的年份。
``endMonth``（整数）（可选）筛选器上限的月份。
示例用法：
query = {
"name": "OpenTargets_get_publications_by_drug_chemblId",
"arguments": {
"entityId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_publications_by_target_ensemblID**（类型：OpenTarget）¶
检索与目标ensemblID相关的出版物，包括PubMed ID和出版日期。
OpenTargets_get_publications_by_target_ensemblID 工具规范
工具信息：
名称:
OpenTargets_get_publications_by_target_ensemblID类型：
OpenTarget描述：检索与目标ensemblID相关的出版物，包括PubMed ID和出版日期。
参数：
entityId(string) (required) The ID of the entity (ensemblID).``additionalIds``（数组）（可选）要在搜索中包含的附加ID列表。
``startYear``（整数）（可选）过滤器下限年份。
``startMonth``（整数）（可选）过滤器下限的月份。
``endYear``（整数）（可选）筛选器高端的年份。
``endMonth``（整数）（可选）筛选器上限的月份。
示例用法：
query = {
"name": "OpenTargets_get_publications_by_target_ensemblID",
"arguments": {
"entityId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_similar_entities_by_disease_efoId**（类型：OpenTarget）¶
使用基于PubMed训练的模型，根据给定疾病的efoId检索相似实体。
OpenTargets_get_similar_entities_by_disease_efoId 工具规范
工具信息：
名称:
OpenTargets_get_similar_entities_by_disease_efoId类型：
OpenTarget描述：使用基于PubMed训练的模型，根据给定疾病的efoId检索相似实体。
参数：
efoId(string) (required) The EFO ID of the disease.threshold(number) (required) Threshold similarity between 0 and 1. Only results above threshold are returned.size(integer) (required) Number of similar entities to fetch.
示例用法：
query = {
"name": "OpenTargets_get_similar_entities_by_disease_efoId",
"arguments": {
"efoId": "example_value",
"threshold": "example_value",
"size": 10
}
}
result = tu.run(query)
**OpenTargets_get_similar_entities_by_drug_chemblId**（类型：OpenTarget）¶
使用基于PubMed训练的模型，根据给定的药物chemblId检索相似实体。
OpenTargets_get_similar_entities_by_drug_chemblId 工具规范
工具信息：
名称:
OpenTargets_get_similar_entities_by_drug_chemblId类型：
OpenTarget描述：使用基于PubMed训练的模型，检索与指定药物chemblId相似的实体。
参数：
chemblId(string) (required) The chemblId of the disease.threshold(number) (required) Threshold similarity between 0 and 1. Only results above threshold are returned.size(integer) (required) Number of similar entities to fetch.
示例用法：
query = {
"name": "OpenTargets_get_similar_entities_by_drug_chemblId",
"arguments": {
"chemblId": "example_value",
"threshold": "example_value",
"size": 10
}
}
result = tu.run(query)
**OpenTargets_get_similar_entities_by_target_ensemblID**（类型：OpenTarget）¶
使用基于PubMed训练的模型，为给定的目标ensemblID检索相似实体。
OpenTargets_get_similar_entities_by_target_ensemblID 工具规范
工具信息：
名称:
OpenTargets_get_similar_entities_by_target_ensemblID类型：
OpenTarget描述：使用基于PubMed训练的模型，为指定的目标ensemblID检索相似实体。
参数：
ensemblId(string) (required) The ensemblID of the disease.threshold(number) (required) Threshold similarity between 0 and 1. Only results above threshold are returned.size(integer) (required) Number of similar entities to fetch.
示例用法：
query = {
"name": "OpenTargets_get_similar_entities_by_target_ensemblID",
"arguments": {
"ensemblId": "example_value",
"threshold": "example_value",
"size": 10
}
}
result = tu.run(query)
**OpenTargets_get_target_classes_by_ensemblID**（类型：OpenTarget）¶
检索与特定目标ensemblID关联的目标类。
OpenTargets_get_target_classes_by_ensemblID 工具规范
工具信息：
名称:
OpenTargets_get_target_classes_by_ensemblID类型：
OpenTarget描述：检索与特定目标ensemblID关联的目标类。
参数：
ensemblId(string) (required) The Ensembl ID of the target.
示例用法：
query = {
"name": "OpenTargets_get_target_classes_by_ensemblID",
"arguments": {
"ensemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_target_constraint_info_by_ensemblID**（类型：OpenTarget）¶
获取特定目标ensemblID的遗传约束信息，包括预期值和其他相关数据。
OpenTargets_get_target_constraint_info_by_ensemblID 工具规范
工具信息：
名称:
OpenTargets_get_target_constraint_info_by_ensemblID类型：
OpenTarget描述：检索特定目标的ensemblID的遗传约束信息，包括预期值、观察值和评分。
参数：
ensemblId(string) (required) The Ensembl ID of the target.
示例用法：
query = {
"name": "OpenTargets_get_target_constraint_info_by_ensemblID",
"arguments": {
"ensemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_target_enabling_packages_by_ensemblID**（类型：OpenTarget）¶
检索与特定目标ensemblID关联的目标启用包（Target Enabling Packages，TEP）。
OpenTargets_get_target_enabling_packages_by_ensemblID 工具规范
工具信息：
名称:
OpenTargets_get_target_enabling_packages_by_ensemblID类型：
OpenTarget描述：检索与特定目标ensemblID关联的目标启用包（Target Enabling Packages, TEP）。
参数：
ensemblId(string) (required) The Ensembl ID of the target.
示例用法：
query = {
"name": "OpenTargets_get_target_enabling_packages_by_ensemblID",
"arguments": {
"ensemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_target_gene_ontology_by_ensemblID**（类型：OpenTarget）¶
通过Ensembl ID检索特定目标的基因本体（Gene Ontology）注释。
OpenTargets_get_target_gene_ontology_by_ensemblID 工具规范
工具信息：
名称:
OpenTargets_get_target_gene_ontology_by_ensemblID类型：
OpenTarget描述：通过Ensembl ID检索特定目标的基因本体注释。
参数：
ensemblId(string) (required) The Ensembl ID of the target for which to retrieve Gene Ontology annotations.
示例用法：
query = {
"name": "OpenTargets_get_target_gene_ontology_by_ensemblID",
"arguments": {
"ensemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_target_genomic_location_by_ensemblID**（类型：OpenTarget）¶
检索特定目标的基因组位置信息，包括染色体、起始位置、结束位置和链方向。
OpenTargets_get_target_genomic_location_by_ensemblID 工具规范
工具信息：
名称:
OpenTargets_get_target_genomic_location_by_ensemblID类型：
OpenTarget描述：检索特定目标的基因组位置信息，包括染色体、起始位置、结束位置和链方向。
参数：
ensemblId(string) (required) The Ensembl ID of the target for which to retrieve genomic location information.
示例用法：
query = {
"name": "OpenTargets_get_target_genomic_location_by_ensemblID",
"arguments": {
"ensemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_target_homologues_by_ensemblID**（类型：OpenTarget）¶
通过 Ensembl ID 获取特定目标的同源序列。
OpenTargets_get_target_homologues_by_ensemblID 工具规范
工具信息：
名称:
OpenTargets_get_target_homologues_by_ensemblID类型：
OpenTarget描述：通过Ensembl ID获取特定目标的同源基因。
参数：
ensemblId(string) (required) The Ensembl ID of the target for which to retrieve homologues.
示例用法：
query = {
"name": "OpenTargets_get_target_homologues_by_ensemblID",
"arguments": {
"ensemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_target_id_description_by_name**（类型：OpenTarget）¶
根据目标名称获取ensemblId和描述。
OpenTargets_get_target_id_description_by_name 工具规范
工具信息：
名称:
OpenTargets_get_target_id_description_by_name类型：
OpenTarget描述：根据目标名称获取ensemblId和描述。
参数：
targetName(string) (required) The name of the target for which the ID is required.
示例用法：
query = {
"name": "OpenTargets_get_target_id_description_by_name",
"arguments": {
"targetName": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_target_interactions_by_ensemblID**（类型：OpenTarget）¶
为特定的目标ensemblID检索交互数据，包括交互伙伴和证据信息…
OpenTargets_get_target_interactions_by_ensemblID 工具规范
工具信息：
名称:
OpenTargets_get_target_interactions_by_ensemblID类型：
OpenTarget描述：检索特定目标ensemblID的交互数据，包括交互伙伴和证据。
参数：
ensemblId(string) (required) The Ensembl ID of the target.``page``（对象）（可选）分页参数。
示例用法：
query = {
"name": "OpenTargets_get_target_interactions_by_ensemblID",
"arguments": {
"ensemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_target_safety_profile_by_ensemblID**（类型：OpenTarget）¶
检索特定目标的Ensembl ID对应的已知目标安全性责任。
OpenTargets_get_target_safety_profile_by_ensemblID 工具规范
工具信息：
名称:
OpenTargets_get_target_safety_profile_by_ensemblID类型：
OpenTarget描述：检索特定目标 Ensembl ID 的已知目标安全性责任。
参数：
ensemblId(string) (required) The Ensembl ID of the target for which to retrieve safety liabilities.
示例用法：
query = {
"name": "OpenTargets_get_target_safety_profile_by_ensemblID",
"arguments": {
"ensemblId": "example_value"
}
}
result = tu.run(query)
OpenTargets_get_target_subcell_locations_by_ensembl_ID (Type: OpenTarget)¶
检索特定目标ensemblID的亚细胞位置相关信息。
OpenTargets_get_target_subcell_locations_by_ensembl_ID tool specification
工具信息：
Name:
OpenTargets_get_target_subcell_locations_by_ensembl_ID类型：
OpenTarget描述：检索特定目标的ensemblID对应的亚细胞位置信息。
参数：
ensemblId(string) (required) The ensemblId of a target.
示例用法：
query = {
"name": "OpenTargets_get_target_subcell_locations_by_ensembl_ID",
"arguments": {
"ensemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_target_synonyms_by_ensemblID**（类型：OpenTarget）¶
检索指定目标的同义词，包括替代名称和符号，使用提供的Ensembl数据。
OpenTargets_get_target_synonyms_by_ensemblID 工具规范
工具信息：
名称:
OpenTargets_get_target_synonyms_by_ensemblID类型：
OpenTarget描述：使用指定的ensemblID检索目标的同义词，包括替代名称和符号。
参数：
ensemblId(string) (required) The Ensembl ID of the target.
示例用法：
query = {
"name": "OpenTargets_get_target_synonyms_by_ensemblID",
"arguments": {
"ensemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_get_target_tractability_by_ensemblID**（类型：OpenTarget）¶
检索特定目标Ensembl ID的可追溯性评估，包括模式和数值。
OpenTargets_get_target_tractability_by_ensemblID 工具规范
工具信息：
名称:
OpenTargets_get_target_tractability_by_ensemblID类型：
OpenTarget描述：检索特定目标 Ensembl ID 的可追溯性评估，包括模式和数值。
参数：
ensemblId(string) (required) The Ensembl ID of the target.
示例用法：
query = {
"name": "OpenTargets_get_target_tractability_by_ensemblID",
"arguments": {
"ensemblId": "example_value"
}
}
result = tu.run(query)
**OpenTargets_multi_entity_search_by_query_string**（类型：OpenTarget）¶
根据查询字符串执行多实体搜索，按实体名称进行过滤，并支持分页操作。
OpenTargets_multi_entity_search_by_query_string 工具规范
工具信息：
名称:
OpenTargets_multi_entity_search_by_query_string类型：
OpenTarget描述：根据查询字符串执行多实体搜索，并通过实体名称和分页设置进行过滤。
参数：
queryString(string) (required) The search string for querying information.``entityNames``（数组）（可选）要搜索的实体名称列表（例如：目标、疾病、药物）。
``page``（对象）（可选）包含索引和大小的分页设置。
示例用法：
query = {
"name": "OpenTargets_multi_entity_search_by_query_string",
"arguments": {
"queryString": "example_value"
}
}
result = tu.run(query)
**OpenTargets_search_category_counts_by_query_string**（类型：OpenTarget）¶
根据查询字符串获取每个实体类别（疾病、靶点、药物）中的条目数量。
OpenTargets_search_category_counts_by_query_string 工具规范
工具信息：
名称:
OpenTargets_search_category_counts_by_query_string类型：
OpenTarget描述：根据查询字符串获取每个实体类别（疾病、靶点、药物）的条目数量。
参数：
queryString(string) (required) The search string for querying information.
示例用法：
query = {
"name": "OpenTargets_search_category_counts_by_query_string",
"arguments": {
"queryString": "example_value"
}
}
result = tu.run(query)
**OpenTargets_target_disease_evidence**（类型：OpenTarget）¶
Explore IntOGen somatic driver evidence for a target-disease association. IMPORTANT: IntOGen only…
OpenTargets_target_disease_evidence 工具规范
工具信息：
名称:
OpenTargets_target_disease_evidence类型：
OpenTargetDescription: Explore IntOGen somatic driver evidence for a target-disease association. IMPORTANT: IntOGen only covers somatic tumor driver mutations — this tool returns empty data ({}) for non-cancer diseases (e.g., type 2 diabetes, hypertension). Empty results are expected and normal when querying non-oncology phenotypes. For non-cancer diseases or to query other data sources, use OpenTargets_get_evidence_by_datasource instead. Accepts gene_symbol (e.g. ‘TP53’) and disease_name (e.g. ‘Crohn disease’) as alternatives to ensemblId/efoId — IDs are auto-resolved via OpenTargets search.
参数：
efoId(string) (optional) EFO/MONDO disease ID (e.g., EFO_0000384). Alternative to disease_name.ensemblId(string) (optional) Ensembl gene ID (e.g., ENSG00000141510). Alternative to gene_symbol.gene_symbol(string) (optional) HGNC gene symbol (e.g., ‘TP53’, ‘BRCA1’). Auto-resolved to ensemblId.disease_name(string) (optional) Disease or phenotype name (e.g., ‘Crohn disease’, ‘breast carcinoma’). Auto-resolved to efoId.
示例用法：
query = {
"name": "OpenTargets_target_disease_evidence",
"arguments": {
}
}
result = tu.run(query)